Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer.

ABSTRACT:

Background

A most important characteristic feature for poor prognosis in colorectal cancer (CRC) is the presence of lymph node metastasis. Determination of carcinoembryonic antigen (CEA) mRNA levels in lymph nodes has proven powerful for quantification of disseminated tumour cells. Here, we investigate the utility of human tissue kallikrein-related peptidase 6 (KLK6) mRNA as a progression biomarker to complement CEA mRNA, for improved selection of patients in need of adjuvant therapy and intensified follow-up after surgery.

Methods

Lymph nodes of pTNM stage I-IV CRC- (166 patients/503 lymph nodes) and control (23/108) patients were collected at surgery and analysed by quantitative RT-PCR.

Results

Lymph node KLK6 positivity was an indicator of poor outcome (hazard rati

SUBMITTER: Ohlsson L 

PROVIDER: S-EPMC3389417 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature