Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer.

ABSTRACT:

Background

Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric cancer, especially in terms of its association with the staining pattern.

Methods

Tissue specimens from 110 gastric cancer patients were immunohistochemically examined. The staining proportion and intensity of mesothelin expression in tumour cells were analysed, and the localisation of mesothelin was classified into luminal membrane and/or cytoplasmic expression.

Results

Mesothelin was positive in 49 cases, and the incidence of mesothelin expression was corr

SUBMITTER: Einama T 

PROVIDER: S-EPMC3389425 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature