Protein dynamics studied with ultrafast two-dimensional infrared vibrational echo spectroscopy.

ABSTRACT: Proteins, enzymes, and other biological molecules undergo structural dynamics as an intrinsic part of their biological functions. While many biological processes occur on the millisecond, second, and even longer time scales, the fundamental structural dynamics that eventually give rise to such processes occur on much faster time scales. Many decades ago, chemical kineticists focused on the inverse of the reaction rate constant as the important time scale for a chemical reaction. However, through transition state theory and a vast amount of experimental evidence, we now know that the key events in a chemical reaction can involve structural fluctuations that take a system of reactants to its transition state, the crossing of a barrier, and the eventual relaxation to product states. Such dyna

SUBMITTER: Thielges MC 

PROVIDER: S-EPMC3389584 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature