BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.

ABSTRACT:

Unlabelled

Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity and computational efficiency.

Availability

http://bioinformatics.mdanderson.org/main/BreakFusion

SUBMITTER: Chen K 

PROVIDER: S-EPMC3389765 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature