Genetic characterization of vocal fold lesions: leukoplakia and carcinoma.

ABSTRACT:

Objectives/hypothesis

Malignant transformation of laryngeal keratosis has been reported in a substantial subset of patients, yet reliable criteria for predicting patients most at risk have yet to be determined. Current methods for determining dysplasia ratings are susceptible to errors in biopsy sampling and interpretation. An understanding of the genetic underpinnings of the progression of vocal fold tumorigenesis may contribute to the creation of reliable and predictive diagnostic criteria. We hypothesized that genetic expression markers distinguish patients with keratotic noncancerous vocal fold lesions from invasive carcinoma.

Study design

Observational cross-sectional study.

Methods

Real-time polymerase chain reaction (RT-PCR) was used to compare expression of 84

SUBMITTER: Bartlett RS 

PROVIDER: S-EPMC3389785 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature