Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress.

ABSTRACT:

Background

Many aging changes seem similar to those elicited by sleep-deprivation and psychosocial stress. Further, sleep architecture changes with age suggest an age-related loss of sleep. Here, we hypothesized that sleep deprivation in young subjects would elicit both stress and aging-like transcriptional responses.

Methodology/principal findings

F344 rats were divided into control and sleep deprivation groups. Body weight, adrenal weight, corticosterone level and hippocampal CA1 transcriptional profiles were measured. A second group of animals was exposed to novel environment stress (NES), and their hippocampal transcriptional profiles measured. A third cohort exposed to control or SD was used to validate transcriptional results with Western blots. Microarray results were

SUBMITTER: Porter NM 

PROVIDER: S-EPMC3390348 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature