Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study.

ABSTRACT:

Background

The liver-secreted protein fetuin-A induces peripheral insulin resistance in vitro. In a pilot study, we observed that higher fetuin-A levels were associated with diabetes mellitus in older persons. However, this finding has not been confirmed in large cohorts. We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD).

Methods and results

Among 3710 community-living individuals ≥ 65 years of age without diabetes mellitus at baseline, fetuin-A was measured in serum collected in 1992 to 1993. Participants were followed up for 10.6 years (median) for incident diabetes mellitus. Cox regression models evaluat

SUBMITTER: Ix JH 

PROVIDER: S-EPMC3390925 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature