MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.

ABSTRACT: High glycolysis, well known as "Warburg effect," is frequently observed in a variety of cancers. Whether the deregulation of miRNAs contributes to the Warburg effect remains largely unknown. Because miRNA regulates gene expression at both mRNA and protein levels, we constructed a gene functional association network, which allows us to detect the gene activity instead of gene expression, to integratively analyze the microarray data for gene expression and miRNA expression profiling and identify glycolysis-related gene-miRNA pairs deregulated in cancer. Hexokinase 2 (HK2), coding for the first rate-limiting enzyme of glycolysis, is among the top list of genes predicted and potentially regulated by multiple miRNAs including miR-143. Interestingly, miR-143 expression was inversely associated w

SUBMITTER: Fang R 

PROVIDER: S-EPMC3391126 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature