Ontology highlight
ABSTRACT:
SUBMITTER: Maezawa Y
PROVIDER: S-EPMC3391250 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Maezawa Yoshiro Y Binnie Matthew M Li Chengjin C Thorner Paul P Hui Chi-Chung CC Alman Benjamin B Taketo Makoto Mark MM Quaggin Susan E SE
PloS one 20120706 7
Conditional gene targeting in mice has provided great insight into the role of gene function in kidney development and disease. Although a number of Cre-driver mouse strains already exist for the kidney, development of additional strains with unique expression patterns is needed. Here we report the generation and validation of a Tcf21/Pod1-Cre driver strain that expresses Cre recombinase throughout the condensing and stromal mesenchyme of developing kidneys and in their derivatives including epi ...[more]