Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes is associated with complications in the central nervous system (CNS), including learning and memory, and an increased risk for neurodegenerative diseases. The mechanism underlying this association is not understood. The aim of this study was to gain greater insight into the possible mechanisms of diabetes-induced cognitive decline.

Methods

We used microarray technology to identify and examine changes in gene expression in the hippocampus of a murine model of type 2 diabetes, the db/db mouse. Bioinformatics approaches were then used to investigate the biological significance of these genes. To validate the biological significance we evaluated mRNA and protein levels.

Results

At 8 and 24 weeks, 256 and 822 genes, respectively, were differ

SUBMITTER: Sims-Robinson C 

PROVIDER: S-EPMC3391332 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature