Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer.

ABSTRACT:

Background

Microtubule-associated proteins (MAPs) endogenously regulate microtubule stability. Here, the prognostic value of stathmin, a destabilizing protein, was assessed in combination with MAP-tau, a stabilizing protein, in order to evaluate microtubule stabilization as a potential biomarker.

Methods

Stathmin and MAP-tau expression levels were measured in a breast cancer cohort (n = 651) using the tissue microarray format and quantitative immunofluorescence (AQUA) technology, then correlated with clinical and pathological characteristics and disease-free survival.

Results

Univariate Cox proportional hazard models indicated that high stathmin expression predicts worse overall survival (hazard ratio [HR] = 1.48; 95% confidence interval [CI] = 1.119-1.966; P = .0061)

SUBMITTER: Baquero MT 

PROVIDER: S-EPMC3391341 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature