Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis.

ABSTRACT:

Aims/hypothesis

We have previously documented a high heritability of insulin clearance in a Hispanic cohort. Here, our goal was to confirm the high heritability in a second cohort and search for genetic loci contributing to insulin clearance.

Methods

Hyperinsulinaemic-euglycaemic clamps were performed in 513 participants from 140 Hispanic families. Heritability was estimated for clamp-derived insulin clearance and a two-phase genome-wide linkage scan was conducted using a variance components approach. Linkage peaks were further investigated by candidate gene association analysis in two cohorts.

Results

The covariate-adjusted heritability of insulin clearance was 73%, indicating that the majority of the phenotypic variance is due to genetic factors. In the Phase 1 link

SUBMITTER: Guo X 

PROVIDER: S-EPMC3391346 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature