Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women.

ABSTRACT:

Objective

To determine the relationship between genetic polymorphisms and environmental factors (skin color) on blood pressure among African American women.

Method

A descriptive study, consisting of 137 African American women from a Midwestern, metropolitan area was conducted. Blood pressure was measured using a digital blood pressure monitor. Self-reporting methods were utilized to obtain information on skin color. Buccal swab saliva samples were obtained for genotyping.

Results

Of the four single nucleotide polymorphisms (SNPs) on the sodium bicarbonate co-transporter gene (SLC4A5) examined in this study, only one SNP (rs10177833) and skin color interaction was found to be associated with systolic blood pressure. The additive effect of rs10177833 on systolic blood p

SUBMITTER: Taylor JY 

PROVIDER: S-EPMC3391738 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature