Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis.

ABSTRACT:

Aim

To determine if the fraction of Nardostachys jatamansi (NJ) has the potential to ameliorate the severity of acute pancreatitis (AP).

Methods

Mice were administered the biologically active fraction of NJ, i.e., the 4th fraction (NJ4), intraperitoneally, and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h. Six hours after the last cerulein injection, the pancreas, lung, and blood were harvested for morphological examination, measurement of cytokine expression, and examination of neutrophil infiltration.

Results

NJ4 administration attenuated the severity of AP and lung injury associated with AP. It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1 (HO-1). Furthermo

SUBMITTER: Bae GS 

PROVIDER: S-EPMC3391759 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature