Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels.

ABSTRACT:

Background

Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 (SCARB1) gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Methods

A total of 598 subjects of Bai Ku Yao and 585 subjects of Han Chinese were randomly selected from our stratified randomized cluster samples. Genotypes of the SCARB1 rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.

Results

The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-

SUBMITTER: Wu DF 

PROVIDER: S-EPMC3391995 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature