Analysis of conformational variation in macromolecular structural models.

ABSTRACT: Experimental conditions or the presence of interacting components can lead to variations in the structural models of macromolecules. However, the role of these factors in conformational selection is often omitted by in silico methods to extract dynamic information from protein structural models. Structures of small peptides, considered building blocks for larger macromolecular structural models, can substantially differ in the context of a larger protein. This limitation is more evident in the case of modeling large multi-subunit macromolecular complexes using structures of the individual protein components. Here we report an analysis of variations in structural models of proteins with high sequence similarity. These models were analyzed for sequence features of the protein, the role of sc

SUBMITTER: Srivastava SK 

PROVIDER: S-EPMC3392262 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature