The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.

ABSTRACT:

Background

Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human families or populations are of particular interest. Histiocytic sarcoma is a rare and poorly understood neoplasm in humans that occurs in 15% to 25% of Bernese Mountain Dogs (BMD).

Methods

Genomic DNA was collected from affected and unaffected BMD in North America and Europe. Both independent and combined genome-wide association studies (GWAS) were used to identify cancer-associated loci. Fine mapping and sequencing narrowed the primary locus to a single gene region.

Results

Both populations shared the same primary locus, wh

SUBMITTER: Shearin AL 

PROVIDER: S-EPMC3392365 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature