Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk.

ABSTRACT:

Background

Prostate cancer (PC) is the most frequently diagnosed solid tumor in U.S. men. Genome-wide association studies (GWAS) have identified over 40 risk-associated single nucleotide polymorphisms (SNPs), including variants in androgen pathway genes (e.g., KLK3 and AR). Androgens are important in PC and genes involved in this pathway are therefore candidates for conferring susceptibility to PC.

Methods

In this hypothesis-testing study, we evaluated PC risk in association with SNPs in 22 candidate genes involved in androgen metabolism or interactions with the androgen receptor (AR). A total of 187 SNPs were genotyped in 1458 cases and 1351 age-matched controls from a population-based study. PC risk was estimated using adjusted unconditional logistic regression and multino

SUBMITTER: Kwon EM 

PROVIDER: S-EPMC3392409 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature