Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

ABSTRACT: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these preclinical models. In this study, we used an unbiased transcriptional network approach to define, in molecular terms, similarities and differences among three lupus models and human LN. Genome-wide gene-expression networks were generated using natural language processing and automated promoter analysis and compared across species via suboptimal graph matching. The three murine models and human LN share both common and unique features. The 20 commonly shared network nodes reflect the key pathologic processes of immune cell infiltration/activation, endothelial ce

SUBMITTER: Berthier CC 

PROVIDER: S-EPMC3392438 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature