Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.

ABSTRACT: Age-related macular degeneration (AMD) is a common condition among the elderly population that leads to the progressive central vision loss and serious compromise of quality of life for its sufferers. It is also one of the few disorders for whom the investigation of its genetics has yielded rich insights into its diversity and causality and holds the promise of enabling clinicians to provide better risk assessments for individuals as well as to develop and selectively deploy new therapeutics to either prevent or slow the development of disease and lessen the threat of vision loss. The genetics of AMD began initially with the appreciation of familial aggregation and increase risk and expanded with the initial association of APOE variants with the disease. The first major breakthroughs came

SUBMITTER: Gorin MB 

PROVIDER: S-EPMC3392516 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature