Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery.

ABSTRACT:

Purpose

To report the esophageal toxicity from single-fraction paraspinal stereotactic radiosurgery (SRS) and identify dosimetric and clinical risk factors for toxicity.

Methods and materials

A total of 204 spinal metastases abutting the esophagus (182 patients) were treated with high-dose single-fraction SRS during 2003-2010. Toxicity was scored using the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 4.0. Dose-volume histograms were combined to generate a comprehensive atlas of complication incidence that identifies risk factors for toxicity. Correlation of dose-volume factors with esophageal toxicity was assessed using Fisher's exact test and logistic regression. Clinical factors were correlated with toxicity.

Results

The median dose

SUBMITTER: Cox BW 

PROVIDER: S-EPMC3392527 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature