Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs.

ABSTRACT:

Objective

To measure the association between use of proton pump inhibitors and a range of harmful outcomes in patients using clopidogrel and aspirin.

Design

Observational cohort study and self controlled case series.

Setting

United Kingdom General Practice Research Database with linked data from the Myocardial Ischaemia National Audit Project (MINAP) and the Office for National Statistics (the cardiovascular disease research using linked bespoke studies and electronic records (CALIBER) collaboration)

Population

24,471 patients receiving clopidogrel and aspirin.

Main outcome measures

The primary outcome was death or incident myocardial infarction. Secondary outcomes were death, incident myocardial infarction, vascular death, and non-vascular death. Compar

SUBMITTER: Douglas IJ 

PROVIDER: S-EPMC3392956 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature