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RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.

ABSTRACT: Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases.

SUBMITTER: Galimand M 

PROVIDER: S-EPMC3393463 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.

Galimand Marc M   Courvalin Patrice P   Lambert Thierry T  

Antimicrobial agents and chemotherapy 20120430 7

Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases. ...[more]

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