Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.

ABSTRACT: The general stress regulon of Bacillus subtilis comprises approximately 200 genes and is under the control of the alternative sigma factor σ(B). The activation of σ(B) occurs in response to multiple physical stress stimuli as well as energy starvation conditions. The expression of the general stress proteins provides growing and stationary nonsporulating vegetative cells with nonspecific and broad stress resistance. A previous comprehensive phenotype screening analysis of 94 general stress gene mutants in response to severe growth-inhibiting stress stimuli, including ethanol, NaCl, heat, and cold, indicated that secondary oxidative stress may be a common component of severe physical stress. Here we tested the individual contributions of the same set of 94 mutants to the development of resi

SUBMITTER: Reder A 

PROVIDER: S-EPMC3393503 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature