Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression.

ABSTRACT:

Background

Normal airway epithelial barrier function is maintained by cell-cell contacts which require the translocation of adhesion proteins at the cell surface, through membrane vesicle trafficking and fusion events. Myoferlin and dysferlin, members of the multiple-C2-domain Ferlin superfamily, have been implicated in membrane fusion processes through the induction of membrane curvature. The objectives of this study were to examine the expression of dysferlin and myoferlin within the human airway and determine the roles of these proteins in airway epithelial homeostasis.

Methods

The expression of dysferlin and myoferlin were evaluated in normal human airway sections by immunohistochemistry, and primary human airway epithelial cells and fibroblasts by immuno blot. Localizat

SUBMITTER: Leung C 

PROVIDER: S-EPMC3393691 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature