Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer.

ABSTRACT:

Purpose

Antiproliferative and antiosteoclastic activity from preclinical models show potential for dasatinib, an oral SRC and SRC family kinase inhibitor, as a targeted therapy for patients with prostate cancer. This phase II study investigated the activity of dasatinib in patients with metastatic castration-resistant prostate cancer (CRPC).

Experimental design

Chemotherapy-naive men with CRPC and increasing prostate-specific antigen were treated with dasatinib 100 or 70 mg twice daily. Endpoints included changes in prostate-specific antigen, bone scans, measurable disease (Response Evaluation Criteria in Solid Tumor), and markers of bone metabolism. Following Prostate Cancer Working Group 2 guidelines, lack of progression according to Response Evaluation Criteria in Solid T

SUBMITTER: Yu EY 

PROVIDER: S-EPMC3394097 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature