BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies.

ABSTRACT: Genome-wide association studies (GWAS) have discovered many loci associated with common disease and quantitative traits. However, most GWAS have not studied the gene-gene interactions (epistasis) that could be important in complex trait genetics. A major challenge in analysing epistasis in GWAS is the enormous computational demands of analysing billions of SNP combinations. Several methods have been developed recently to address this, some using computers equipped with particular graphical processing units, most restricted to binary disease traits and all poorly suited to general usage on the most widely used operating systems. We have developed the BiForce Toolbox to address the demand for high-throughput analysis of pairwise epistasis in GWAS of quantitative and disease traits across all

SUBMITTER: Gyenesei A 

PROVIDER: S-EPMC3394281 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature