Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure.

ABSTRACT: Antibodies are capable of specifically recognizing and binding antigens. Identification of the antigen-binding site, commonly dubbed paratope, is of high importance both for medical and biological applications. To date, the identification of antigen-binding regions (ABRs) relies on tools for the identification of complementarity-determining regions (CDRs). However, we have shown that up to 22% of the residues that actually bind the antigen fall outside the traditionally defined CDRs. The Paratome web server predicts the ABRs of an antibody, given its amino acid sequence or 3D structure. It is based on a set of consensus regions derived from a structural alignment of a non-redundant set of all known antibody-antigen complexes. Given a query sequence or structure, the server identifies the r

SUBMITTER: Kunik V 

PROVIDER: S-EPMC3394289 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature