PepSite: prediction of peptide-binding sites from protein surfaces.

ABSTRACT: Complex biological functions emerge through intricate protein-protein interaction networks. An important class of protein-protein interaction corresponds to peptide-mediated interactions, in which a short peptide stretch from one partner interacts with a large protein surface from the other partner. Protein-peptide interactions are typically of low affinity and involved in regulatory mechanisms, dynamically reshaping protein interaction networks. Due to the relatively small interaction surface, modulation of protein-peptide interactions is feasible and highly attractive for therapeutic purposes. Unfortunately, the number of available 3D structures of protein-peptide interfaces is very limited. For typical cases where a protein-peptide structure of interest is not available, the PepSite web

SUBMITTER: Trabuco LG 

PROVIDER: S-EPMC3394340 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature