Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye.

ABSTRACT:

Purpose

This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle.

Methods

Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevacizumab, and polymeric particles (20 nm to 10 μm in diameter) were performed using microneedles in New Zealand white rabbits. The fluorescence intensity within the eye was monitored in each animal using an ocular fluorophotometer to determine the distribution of the injected material in the eye over time as compared with intravitreal injection of fluorescein. Fundus photography and histology were performed as well.

Results

Molecules and particles injected near the limbus using

SUBMITTER: Patel SR 

PROVIDER: S-EPMC3394664 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature