Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.

ABSTRACT: Multiple sclerosis (MS) is a neuroinflammatory disease characterized by a progressive loss of myelin and a failure of oligodendrocyte (OL)-mediated remyelination, particularly in the progressive phases of the disease. An improved understanding of the signaling mechanisms that control differentiation of OL precursors may lead to the identification of new therapeutic targets for remyelination in MS. About 100 mammalian Protein Tyrosine Phosphatases (PTPs) are known, many of which are involved in signaling both in health and disease. We have undertaken a systematic genomic approach to evaluate PTP gene activity in multiple sclerosis autopsies and in related in vivo and in vitro models of the disease. This effort led to the identification of Dusp15/VHY, a PTP previously believed to be expresse

SUBMITTER: Schmidt F 

PROVIDER: S-EPMC3394735 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature