Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice.

ABSTRACT:

Background

Modifications of adjuvants that induce cell-mediated over antibody-mediated immunity is desired for development of vaccines. Nanocapsules have been found to be viable adjuvants and are amenable to engineering for desired immune responses. We previously showed that natural nanocapsules called vaults can be genetically engineered to elicit Th1 immunity and protection from a mucosal bacterial infection. The purpose of our study was to characterize immunity produced in response to OVA within vault nanoparticles and compare it to another nanocarrier.

Methodology and principal findings

We characterized immunity resulting from immunization with the model antigen, ovalbumin (OVA) encased in vault nanocapsules and liposomes. We measured OVA responsive CD8(+) and CD4(+) mem

SUBMITTER: Kar UK 

PROVIDER: S-EPMC3394761 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature