Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer.

ABSTRACT: Relationships are unclear between polymorphisms in genes involved in metabolism and detoxification of various chemicals and papillary thyroid cancer (PTC) risk as well as their potential modification by alcohol or tobacco intake. We evaluated associations between 1647 tagging single nucleotide polymorphisms (SNPs) in 132 candidate genes/regions involved in metabolism of exogenous and endogenous compounds (Phase I/II, oxidative stress, and metal binding pathways) and PTC risk in 344 PTC cases and 452 controls. For 15 selected regions and their respective SNPs, we also assessed interaction with alcohol and tobacco use. Logistic regression models were used to evaluate the main effect of SNPs (P(trend)) and interaction with alcohol/tobacco intake. Gene- and pathway-level associations and inter

SUBMITTER: Aschebrook-Kilfoy B 

PROVIDER: S-EPMC3394851 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature