The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.

ABSTRACT: Granulocyte-macrophage colony stimulating factor (GM-CSF) promotes the growth, survival, differentiation and activation of normal myeloid cells and is essential for fully functional macrophage differentiation in vivo. To better understand the mechanisms by which growth factors control the balance between proliferation and self-renewal versus growth-suppression and differentiation we have used the bi-potent FDB1 myeloid cell line, which proliferates in IL-3 and differentiates to granulocytes and macrophages in response to GM-CSF. This provides a manipulable model in which to dissect the switch between growth and differentiation. We show that, in the context of signaling from an activating mutant of the GM-CSF receptor β subunit, a single intracellular tyrosine residue (Y577) mediates the gr

SUBMITTER: Brown AL 

PROVIDER: S-EPMC3394929 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature