Ontology highlight
ABSTRACT:
SUBMITTER: Holland DG
PROVIDER: S-EPMC3395113 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20110218 3
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene and protein expression and was associated with a distinct expression signature and poor clinical outcome. ZNF703 transformed NIH 3T3 fibroblasts, behaving as ...[more]