The design and screening of drugs to prevent acquired sensorineural hearing loss.

ABSTRACT:

Introduction

Sensorineural hearing loss affects a high percentage of the population. Ototoxicity is a serious and pervasive problem in patients treated with cisplatin. Strategies to ameliorate ototoxicity without compromising on antitumor activity of treatments are urgently needed. Similar problems occur with aminoglycoside antibiotic therapy for infections. Noise-induced hearing loss affects a large number of people. The use of ear protection is not always possible or effective. The prevention of hearing loss with drug therapy would have a huge impact in reducing the number of people with hearing loss from these major causes.

Areas covered

This review discusses significant research findings dealing with the use of protective agents against hearing loss caused by cisplatin,

SUBMITTER: Mukherjea D 

PROVIDER: S-EPMC3395201 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature