Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms.

ABSTRACT:

Background and purpose

The Living Well With Stroke study has demonstrated effectiveness of a brief psychosocial treatment in reducing depressive symptoms after stroke. The purpose of this analysis was to determine whether key variables associated with prevalence of poststroke depression also predicted treatment response.

Methods

Response to a brief psychosocial/behavioral intervention for poststroke depression was measured with the Hamilton Rating Scale for Depression. Analysis of covariance models tested for interaction of potential predictor variables with treatment group on percent change in Hamilton Rating Scale for Depression from pre- to post-treatment as an outcome.

Results

Initial depression severity, hemispheric location, level of social support, age, gender,

SUBMITTER: Kohen R 

PROVIDER: S-EPMC3395370 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature