The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells.

ABSTRACT: The transcription factor DLX3 plays a decisive role in bone development of vertebrates. In neural-crest derived stem cells from the dental follicle (DFCs), DLX3 is differentially expressed during osteogenic differentiation, while other osteogenic transcription factors such as DLX5 or RUNX2 are not highly induced. DLX3 has therefore a decisive role in the differentiation of DFCs, but its actual biological effects and regulation are unknown. This study investigated the DLX3-regulated processes in DFCs. After DLX3 overexpression, DFCs acquired a spindle-like cell shape with reorganized actin filaments. Here, marker genes for cell morphology, proliferation, apoptosis, and osteogenic differentiation were significantly regulated as shown in a microarray analysis. Further experiments showed that

SUBMITTER: Viale-Bouroncle S 

PROVIDER: S-EPMC3396153 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature