Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice.

ABSTRACT:

Background

The use of niacin in the treatment of dyslipidemias is limited by the common side effect of cutaneous vasodilation, commonly termed flushing. Flushing is thought to be due to release of the vasodilatory prostanoids prostaglandin D2 (PGD2) and prostaglandin E2 from arachidonic acid metabolism through the cyclooxygenase pathway. Arachidonic acid is also metabolized by the cytochrome P450 system, which is regulated, in part, by the enzyme soluble epoxide hydrolase (sEH).

Methods

These experiments used an established murine model in which ear tissue perfusion was measured by laser Doppler to test the hypothesis that inhibition of sEH would limit niacin-induced flushing.

Results

Niacin-induced flushing was reduced from 506 ± 126% to 213 ± 39% in sEH knockout ani

SUBMITTER: Inceoglu AB 

PROVIDER: S-EPMC3396292 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature