Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study.

ABSTRACT:

Background

Few studies have evaluated the association between the n-3 fatty acid α-linolenic acid (ALA) and the incidence of congestive heart failure (CHF).

Objective

We investigated whether plasma phospholipid concentrations and estimated dietary consumption of ALA are associated with incident CHF.

Design

We used data from the Cardiovascular Health Study, a prospective cohort study of cardiovascular diseases among adults aged ≥65 y, from 4 US communities. A total of 2957 participants free of prevalent heart disease and with available fatty acid measurements were included in biomarker analyses (30,722 person-years and 686 incident CHF events). A total of 4432 participants free of prevalent heart disease were included in dietary analyses (52,609 person-years and 1072 e

SUBMITTER: Lemaitre RN 

PROVIDER: S-EPMC3396442 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature