Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

ABSTRACT:

Objective

A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA.

Methods

56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections.

Results

Significant evidence for association with suscepti

SUBMITTER: Bowes J 

PROVIDER: S-EPMC3396450 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature