Ontology highlight
ABSTRACT:
SUBMITTER: Mayne L
PROVIDER: S-EPMC3396559 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Journal of the American Society for Mass Spectrometry 20110914 11
Measurement of the naturally occurring hydrogen exchange (HX) behavior of proteins can in principle provide highly resolved thermodynamic and kinetic information on protein structure, dynamics, and interactions. The HX fragment separation-mass spectrometry method (HX-MS) is able to measure hydrogen exchange in biologically important protein systems that are not accessible to NMR methods. In order to achieve high structural resolution in HX-MS experiments, it will be necessary to obtain many sequ ...[more]