Single agent maintenance therapy for advanced stage non-small cell lung cancer: a meta-analysis.

ABSTRACT:

Background

Maintenance therapy is a new treatment paradigm for advanced non-small cell lung cancer (NSCLC). We conducted a meta-analysis of randomized studies with single agent maintenance therapy.

Methods

An electronic literature search of public databases (MEDLINE, EMBASE, Cochrane library) and manual search of relevant conference proceedings was performed. A formal meta-analysis was conducted using Comprehensive Meta Analysis software (Version 2.0). Outcome data were pooled and reported as hazard ratio (HR). The primary outcome of interest was overall survival (OS) and secondary outcome was progression free survival (PFS).

Results

Twelve studies were included (5 meeting abstracts, 7 full manuscripts) with a total of 4286 patients (maintenance arm/control arm - 2449

SUBMITTER: Behera M 

PROVIDER: S-EPMC3396772 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature