Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects.

ABSTRACT: Tissue engineering has recently become available as a treatment procedure for bone augmentation. However, this procedure has several problems, such as high capital investment and expensive cell culture, complicated safety and quality management issues regarding cell handling, and patient problems with the invasive procedure of cell collection. Moreover, it was reported that stem cells secrete many growth factors and chemokines during their cultivation, which could affect cellular characteristics and behavior. This study investigated the effect of stem-cell-cultured conditioned media on bone regeneration. Cultured conditioned media from human bone marrow-derived mesenchymal stem cells (MSC-CM) enhanced the migration, proliferation, and expression of osteogenic marker genes, such as osteocal

SUBMITTER: Osugi M 

PROVIDER: S-EPMC3397118 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature