Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroids.

ABSTRACT:

Objective

To examine whether treatment with antenatal corticosteroids modifies the immediate and long-term effects of prophylactic indomethacin sodium trihydrate in extremely low-birth-weight infants.

Design

Post hoc subgroup analysis of data from the Trial of Indomethacin Prophylaxis in Preterms.

Setting

Thirty-two neonatal intensive care units in Canada, the United States, Australia, New Zealand, and Hong Kong.

Participants

A total of 1195 infants with birth weights of 500 to 999 g and known exposure to antenatal corticosteroids. We defined as adequate any exposure to antenatal corticosteroids that occurred at least 24 hours before delivery.

Intervention

Indomethacin or placebo intravenously once daily for the first 3 days.

Outcome measures

Deat

SUBMITTER: Schmidt B 

PROVIDER: S-EPMC3397141 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature