Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

ABSTRACT:

Background

Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI.

Methods and results

Computed tomography was used to assess quantity of CAC. A meta-analysis of genome-wide association studies for CAC was performed in 9961 men and women from 5 independent community-based cohorts, with replication in 3 additional independent cohorts (n=6032). We examined the top single-nucleotide polymorphisms (SNPs) associated with CAC quantity for association with MI in multiple large genome-wide association studies of MI. Genome-wide significant assoc

SUBMITTER: O'Donnell CJ 

PROVIDER: S-EPMC3397173 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature