A genomic bias for genotype-environment interactions in C. elegans.

ABSTRACT: The phenotype of an organism is determined by its genotype and environment. An interaction between these two arises from the differential effect of the environment on gene expression in distinct genotypes; however, the genomic properties identifying these are not well understood. Here we analyze the transcriptomes of five C. elegans strains (genotype) cultivated in five growth conditions (environment), and find that highly regulated genes, as distinguished by intergenic lengths, motif concentration, and expression levels, are particularly biased toward genotype-environment interactions. Sequencing these strains, we find that genes with expression variation across genotypes are enriched for promoter single-nucleotide polymorphisms (SNPs), as expected. However, genes with genotype-environmen

SUBMITTER: Grishkevich V 

PROVIDER: S-EPMC3397417 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature