Genome-wide DNA methylation changes between the superficial and deep backfat tissues of the pig.

ABSTRACT: Adipose tissue is not only a storage organ involved in fuel metabolism, but also an endocrine organ involved in the regulation of insulin sensitivity, thermogenesis, immunity, and inflammation. There are anatomical, cellular, molecular and physiological differences among adipose tissues deposited in different body sites. However, current understanding of the intrinsic differences between the sub-compartments of the subcutaneous adipose tissue remains rudimentary. Here, we analyzed the genome-wide DNA methylation differences between the porcine superficial and deep backfat tissues using methylated DNA immunoprecipitation combined with high-throughput sequencing. We show that the genes with differentially methylated regions in their promoter are mainly involved in the processes of "lipid met

SUBMITTER: Li M 

PROVIDER: S-EPMC3397513 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature