Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation.

ABSTRACT:

Objectives

Sleep is regulated by circadian and homeostatic processes and is highly organized temporally. Our study was designed to determine whether this organization is preserved in patients receiving mechanical ventilation (MV) and intravenous sedation.

Design

Observational study.

Setting

Academic medical intensive care unit.

Patients

Critically ill patients receiving MV and intravenous sedation.

Methods

Continuous polysomnography (PSG) was initiated an average of 2.0 (1.0, 3.0) days after ICU admission and continued ≥ 36 h or until the patient was extubated. Sleep staging and power spectral analysis were performed using standard approaches. We also calculated the electroencephalography spectral edge frequency 95% SEF₉₅, a parameter that is normally hi

SUBMITTER: Gehlbach BK 

PROVIDER: S-EPMC3397814 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature