Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

ABSTRACT:

Background

In addition to lowering cholesterol, statins are thought to beneficially modulate inflammation. Several chemokines including CXCL1/growth-related oncogene (GRO)-α, CXCL8/interleukin (IL)-8 and CCL2/monocyte chemoattractant protein (MCP)-1 are important in the pathogenesis of atherosclerosis and can be influenced by statin-treatment. Recently, we observed that atorvastatin-treatment alters the intracellular content and subcellular distribution of GRO-α in cultured human umbilical vein endothelial cells (HUVECs). The objective of this study was to investigate the mechanisms involved in this phenomenon.

Methodology/ principal findings

The effect of atorvastatin on secretion levels and subcellular distribution of GRO-α, IL-8 and MCP-1 in HUVECs activated by interleuki

SUBMITTER: Hol J 

PROVIDER: S-EPMC3398041 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature